This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for NETO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NETO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NETO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:46,883,418–46,885,208 | 259.5 kb | Distal (>10kb) Multiome | 969 | |
| chr16:46,885,524–46,886,746 | 257.4 kb | Distal (>10kb) Multiome | 318 | |
| chr16:46,972,819–46,974,091 | 170.0 kb | Distal (>10kb) Multiome | 975 | |
| chr16:47,037,293–47,038,472 | 105.8 kb | Distal (>10kb) Multiome | 771 | |
| chr16:47,141,742–47,142,111 | 1.6 kb | Proximal (<10kb) | 479 | |
| chr16:47,142,822–47,145,065 | 83 bp | At TSS Multiome | 802 | |
| chr16:47,873,533–47,876,243 | 730.8 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr16:48,050,630–48,051,441 | 907.4 kb | Distal (>10kb) Multiome HiCAR | 61 | |
| chr16:48,117,171–48,117,887 | 973.9 kb | Distal (>10kb) Multiome HiCAR | 334 |
Genomic view of the NETO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.