This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for NENF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NENF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NENF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:212,214,185–212,214,767 | 218.3 kb | Distal (>10kb) Multiome | 99 | |
| chr1:212,284,406–212,286,816 | 147.8 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:212,309,881–212,310,794 | 122.7 kb | Distal (>10kb) Multiome | 183 | |
| chr1:212,315,914–212,316,445 | 116.8 kb | Distal (>10kb) Multiome | 140 | |
| chr1:212,413,972–212,416,004 | 18.0 kb | Distal (>10kb) Multiome | 833 | |
| chr1:212,432,597–212,433,702 | 27 bp | At TSS Multiome | 576 | |
| chr1:212,477,008–212,477,651 | 44.4 kb | Distal (>10kb) Multiome | 419 | |
| chr1:212,498,151–212,499,452 | 66.0 kb | Distal (>10kb) Multiome | 216 | |
| chr1:212,514,035–212,515,926 | 82.5 kb | Distal (>10kb) Multiome | 524 | |
| chr1:212,558,067–212,559,384 | 126.1 kb | Distal (>10kb) Multiome | 891 | |
| chr1:212,605,830–212,610,097 | 176.8 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:212,629,910–212,630,849 | 197.4 kb | Distal (>10kb) Multiome | 331 | |
| chr1:212,665,118–212,665,789 | 232.6 kb | Distal (>10kb) Multiome | 678 | |
| chr1:212,698,874–212,700,500 | 266.5 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the NENF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.