This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for NELL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NELL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NELL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:20,386,914–20,388,428 | 282.0 kb | Distal (>10kb) Multiome | 1064 | |
| chr11:20,610,140–20,610,669 | 59.3 kb | Distal (>10kb) Multiome | 413 | |
| chr11:20,668,250–20,668,632 | 937 bp | At TSS | 59 | |
| chr11:20,668,814–20,671,777 | at TSS | At TSS | 336 | |
| chr11:20,671,909–20,672,263 | 2.3 kb | Proximal (<10kb) | 76 | |
| chr11:20,672,717–20,672,951 | 3.1 kb | Proximal (<10kb) | 58 |
Genomic view of the NELL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.