The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for NEK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:169,334,284–169,334,914 | 278.1 kb | Distal (>10kb) Multiome | 96 | |
| chr4:169,347,007–169,347,496 | 265.4 kb | Distal (>10kb) Multiome | 18 | |
| chr4:169,611,998–169,613,442 | 20 bp | At TSS Multiome | 840 | |
| chr4:169,619,326–169,619,817 | 6.7 kb | Proximal (<10kb) | 291 | |
| chr4:169,619,912–169,621,246 | 7.8 kb | Proximal (<10kb) Multiome | 896 | |
| chr4:169,757,346–169,758,297 | 145.3 kb | Distal (>10kb) Multiome | 724 | |
| chr4:169,774,514–169,775,438 | 162.4 kb | Distal (>10kb) Multiome | 195 | |
| chr4:170,025,638–170,027,809 | 414.9 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr4:170,089,100–170,090,754 | 477.5 kb | Distal (>10kb) Multiome HiCAR | 761 |
Genomic view of the NEK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.