This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for NECTIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NECTIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NECTIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,009,562–111,010,723 | 61.5 kb | Distal (>10kb) Multiome | 118 | |
| chr3:111,063,188–111,064,109 | 7.7 kb | Proximal (<10kb) | 73 | |
| chr3:111,070,119–111,072,931 | 160 bp | At TSS Multiome | 745 | |
| chr3:111,076,700–111,076,996 | 4.9 kb | Proximal (<10kb) | 33 | |
| chr3:111,080,467–111,080,609 | 8.7 kb | Proximal (<10kb) | 66 | |
| chr3:111,082,053–111,082,421 | 7.2 kb | Proximal (<10kb) | 13 | |
| chr3:111,087,718–111,088,464 | 16.3 kb | Distal (>10kb) Multiome | 146 | |
| chr3:111,210,652–111,211,631 | 139.3 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the NECTIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.