Enables identical protein binding activity. Predicted to be involved in regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Located in cilium; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NECAB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NECAB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NECAB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:90,644,726–90,647,850 | 145.7 kb | Distal (>10kb) Multiome HiCAR | 987 | |
| chr8:90,786,514–90,787,153 | 4.6 kb | Proximal (<10kb) | 11 | |
| chr8:90,791,022–90,792,433 | 86 bp | At TSS Multiome | 362 | |
| chr8:90,984,601–90,986,072 | 193.5 kb | Distal (>10kb) Multiome | 606 | |
| chr8:91,040,121–91,041,552 | 249.0 kb | Distal (>10kb) Multiome | 777 | |
| chr8:91,069,419–91,071,048 | 278.4 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the NECAB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.