This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for NDUFS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:1,523,066–1,524,710 | 277.3 kb | Distal (>10kb) Multiome | 630 | |
| chr5:1,593,846–1,595,021 | 206.8 kb | Distal (>10kb) Multiome | 682 | |
| chr5:1,633,700–1,634,325 | 167.4 kb | Distal (>10kb) Multiome | 745 | |
| chr5:1,644,948–1,645,570 | 156.3 kb | Distal (>10kb) Multiome | 437 | |
| chr5:1,666,897–1,668,526 | 134.1 kb | Distal (>10kb) Multiome | 301 | |
| chr5:1,799,167–1,800,245 | 1.6 kb | Proximal (<10kb) Multiome | 744 | |
| chr5:1,800,343–1,801,861 | 6 bp | At TSS Multiome | 895 | |
| chr5:1,801,960–1,802,143 | 554 bp | At TSS | 100 | |
| chr5:1,827,805–1,828,459 | 26.8 kb | Distal (>10kb) Multiome | 84 | |
| chr5:1,867,435–1,868,302 | 66.3 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr5:1,874,486–1,877,084 | 73.6 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr5:1,880,966–1,883,137 | 81.2 kb | Distal (>10kb) Multiome | 459 | |
| chr5:1,883,292–1,884,343 | 82.5 kb | Distal (>10kb) Multiome | 279 | |
| chr5:1,884,792–1,888,153 | 85.8 kb | Distal (>10kb) Multiome | 186 | |
| chr5:1,930,629–1,931,989 | 129.6 kb | Distal (>10kb) Multiome | 233 | |
| chr5:2,038,286–2,039,379 | 237.3 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the NDUFS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.