This gene encodes a protein that localizes to mitochondria and contains a predicted phytoene synthase domain. The encoded protein plays an important role in the assembly of complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain through regulation of subunit ND1 biogenesis. Mutations in this gene are associated with complex I enzymatic deficiency. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for NDUFAF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFAF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFAF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,822,329–94,823,941 | 201.8 kb | Distal (>10kb) Multiome | 818 | |
| chr8:94,894,252–94,897,051 | 129.5 kb | Distal (>10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 75.5 kb | Distal (>10kb) Multiome | 850 | |
| chr8:95,024,342–95,025,424 | 26 bp | At TSS Multiome | 980 | |
| chr8:95,132,764–95,134,804 | 108.7 kb | Distal (>10kb) Multiome | 917 | |
| chr8:95,268,225–95,270,513 | 244.8 kb | Distal (>10kb) Multiome | 1069 |
Genomic view of the NDUFAF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.