This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for NDUFA13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,224,938–19,225,553 | 291.0 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 254.5 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 243.1 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 195.5 kb | Distal (>10kb) Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 130.6 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 110.6 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 53.9 kb | Distal (>10kb) Multiome | 345 | |
| chr19:19,515,735–19,516,510 | 31 bp | At TSS Multiome | 824 | |
| chr19:19,532,119–19,532,674 | 16.2 kb | Distal (>10kb) Multiome | 405 | |
| chr19:19,538,087–19,538,726 | 22.1 kb | Distal (>10kb) Multiome | 255 | |
| chr19:19,539,681–19,541,846 | 25.1 kb | Distal (>10kb) Multiome | 352 | |
| chr19:19,575,151–19,576,000 | 59.4 kb | Distal (>10kb) Multiome | 128 | |
| chr19:19,618,285–19,619,315 | 102.6 kb | Distal (>10kb) Multiome | 414 | |
| chr19:19,627,596–19,629,138 | 112.2 kb | Distal (>10kb) Multiome | 543 | |
| chr19:19,637,337–19,638,344 | 121.4 kb | Distal (>10kb) Multiome | 153 | |
| chr19:19,643,155–19,644,142 | 127.5 kb | Distal (>10kb) Multiome HiCAR | 595 | |
| chr19:19,663,091–19,664,414 | 147.7 kb | Distal (>10kb) Multiome | 848 | |
| chr19:19,668,196–19,669,404 | 152.5 kb | Distal (>10kb) Multiome | 778 | |
| chr19:19,732,628–19,733,489 | 216.9 kb | Distal (>10kb) Multiome | 701 | |
| chr19:19,775,960–19,777,126 | 260.3 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the NDUFA13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.