NDUFA11

NADH:ubiquinone oxidoreductase subunit A11 | B14.7

This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Member of: DE-1 DE-1.12

Biological processes 12 terms

aerobic respiration (GO:0009060)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)

Expression (TPM)

TFs regulating NDUFA11 0 TFs

Transcription factors with Perturb-seq knockdown data for NDUFA11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NDUFA11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:5,621,964–5,623,739	280.8 kb	Distal (>10kb) Multiome	857
chr19:5,679,757–5,681,464	223.0 kb	Distal (>10kb) Multiome	884
chr19:5,686,329–5,687,994	216.7 kb	Distal (>10kb) Multiome	693
chr19:5,689,735–5,690,874	213.5 kb	Distal (>10kb) Multiome	960
chr19:5,719,717–5,721,174	183.4 kb	Distal (>10kb) Multiome	985
chr19:5,790,527–5,791,509	112.9 kb	Distal (>10kb) Multiome	965
chr19:5,803,750–5,806,128	98.6 kb	Distal (>10kb) Multiome HiCAR	858
chr19:5,826,528–5,829,726	75.7 kb	Distal (>10kb) Multiome	1037
chr19:5,903,474–5,905,358	816 bp	At TSS Multiome	1027
chr19:5,977,406–5,978,787	74.4 kb	Distal (>10kb) Multiome	1028
chr19:6,110,281–6,110,936	206.9 kb	Distal (>10kb) Multiome	518
chr19:6,199,134–6,200,121	295.9 kb	Distal (>10kb) Multiome	769

Genome Browser

Genomic view of the NDUFA11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.