The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for NDUFA10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,021,590–240,021,809 | 3.5 kb | Proximal (<10kb) | 126 | |
| chr2:240,024,894–240,026,128 | 152 bp | At TSS Multiome | 890 | |
| chr2:240,089,041–240,090,019 | 64.1 kb | Distal (>10kb) Multiome | 126 | |
| chr2:240,095,861–240,096,471 | 70.8 kb | Distal (>10kb) Multiome | 110 | |
| chr2:240,135,834–240,136,678 | 111.0 kb | Distal (>10kb) Multiome | 753 | |
| chr2:240,232,596–240,234,436 | 208.1 kb | Distal (>10kb) Multiome | 492 |
Genomic view of the NDUFA10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.