This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for NCOA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,726,765–45,727,627 | 303.4 kb | Distal (>10kb) Multiome | 520 | |
| chr10:46,023,121–46,023,829 | 7.2 kb | Proximal (<10kb) Multiome | 900 | |
| chr10:46,028,695–46,029,115 | 5.2 kb | Proximal (<10kb) | 308 | |
| chr10:46,030,064–46,031,227 | 20 bp | At TSS Multiome | 853 | |
| chr10:46,031,732–46,031,930 | 8.3 kb | Proximal (<10kb) | 161 | |
| chr10:46,032,033–46,032,325 | 8.6 kb | Proximal (<10kb) | 397 | |
| chr10:46,047,885–46,048,755 | 17.7 kb | Distal (>10kb) Multiome | 277 | |
| chr10:46,052,126–46,053,175 | 22.0 kb | Distal (>10kb) Multiome | 517 | |
| chr10:46,106,177–46,107,298 | 76.1 kb | Distal (>10kb) Multiome | 610 | |
| chr10:46,228,286–46,229,571 | 198.8 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr10:46,282,489–46,283,279 | 252.4 kb | Distal (>10kb) Multiome | 160 | |
| chr10:46,284,312–46,285,217 | 254.1 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the NCOA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.