Enables ribosome binding activity. Involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NCLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,900,564–2,901,033 | 285.1 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 240.9 kb | Distal (>10kb) Multiome HiCAR | 891 | |
| chr19:2,950,070–2,951,291 | 235.1 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr19:2,976,688–2,977,848 | 208.5 kb | Distal (>10kb) Multiome HiCAR | 715 | |
| chr19:2,983,511–2,984,586 | 201.8 kb | Distal (>10kb) Multiome HiCAR | 523 | |
| chr19:3,024,668–3,025,742 | 160.8 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 149.5 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,041,823–3,042,438 | 143.7 kb | Distal (>10kb) Multiome | 173 | |
| chr19:3,045,731–3,048,029 | 139.9 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 123.4 kb | Distal (>10kb) Multiome | 369 | |
| chr19:3,093,786–3,095,227 | 91.7 kb | Distal (>10kb) Multiome | 515 | |
| chr19:3,095,637–3,096,163 | 89.9 kb | Distal (>10kb) Multiome | 256 | |
| chr19:3,185,009–3,185,331 | 603 bp | At TSS | 307 | |
| chr19:3,185,437–3,186,577 | 183 bp | At TSS Multiome | 751 | |
| chr19:3,224,482–3,224,897 | 38.7 kb | Distal (>10kb) Multiome | 253 | |
| chr19:3,275,036–3,277,129 | 90.3 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,284,276–3,286,396 | 99.6 kb | Distal (>10kb) Multiome | 555 | |
| chr19:3,360,114–3,360,563 | 174.3 kb | Distal (>10kb) Multiome | 430 | |
| chr19:3,434,837–3,435,636 | 249.3 kb | Distal (>10kb) Multiome | 777 | |
| chr19:3,441,686–3,442,206 | 256.0 kb | Distal (>10kb) Multiome | 86 | |
| chr19:3,444,085–3,444,710 | 258.5 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the NCLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.