The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NCBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,665,925–196,666,686 | 276.3 kb | Distal (>10kb) Multiome | 439 | |
| chr3:196,711,809–196,713,001 | 230.1 kb | Distal (>10kb) Multiome | 782 | |
| chr3:196,739,555–196,740,517 | 202.6 kb | Distal (>10kb) Multiome | 736 | |
| chr3:196,867,462–196,868,618 | 74.7 kb | Distal (>10kb) Multiome | 794 | |
| chr3:196,941,814–196,943,294 | 16 bp | At TSS Multiome | 1027 | |
| chr3:196,948,413–196,948,665 | 5.9 kb | Proximal (<10kb) | 308 | |
| chr3:196,968,365–196,969,147 | 26.2 kb | Distal (>10kb) Multiome | 597 | |
| chr3:196,969,208–196,970,172 | 27.5 kb | Distal (>10kb) Multiome | 714 | |
| chr3:197,002,398–197,004,003 | 60.6 kb | Distal (>10kb) Multiome | 569 | |
| chr3:197,028,743–197,030,204 | 87.3 kb | Distal (>10kb) Multiome | 646 |
Genomic view of the NCBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.