This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for NAV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:201,448,161–201,448,846 | 291.5 kb | Distal (>10kb) Multiome | 392 | |
| chr1:201,468,360–201,469,993 | 270.7 kb | Distal (>10kb) Multiome | 750 | |
| chr1:201,480,274–201,481,139 | 259.2 kb | Distal (>10kb) Multiome | 523 | |
| chr1:201,481,427–201,482,595 | 257.7 kb | Distal (>10kb) Multiome | 609 | |
| chr1:201,506,847–201,507,390 | 232.7 kb | Distal (>10kb) Multiome | 605 | |
| chr1:201,512,054–201,512,924 | 227.6 kb | Distal (>10kb) Multiome | 287 | |
| chr1:201,538,592–201,540,560 | 199.6 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr1:201,559,535–201,560,001 | 180.0 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr1:201,614,255–201,614,715 | 125.5 kb | Distal (>10kb) Multiome | 227 | |
| chr1:201,648,049–201,650,866 | 89.5 kb | Distal (>10kb) Multiome | 533 | |
| chr1:201,678,604–201,679,421 | 60.9 kb | Distal (>10kb) Multiome | 158 | |
| chr1:201,709,409–201,709,946 | 30.2 kb | Distal (>10kb) Multiome | 258 | |
| chr1:201,739,028–201,740,430 | 110 bp | At TSS Multiome | 287 | |
| chr1:201,828,821–201,829,863 | 89.4 kb | Distal (>10kb) Multiome | 821 | |
| chr1:201,888,189–201,889,202 | 148.9 kb | Distal (>10kb) Multiome | 335 | |
| chr1:201,895,782–201,896,239 | 156.2 kb | Distal (>10kb) Multiome | 606 | |
| chr1:201,941,439–201,942,399 | 202.1 kb | Distal (>10kb) Multiome | 508 | |
| chr1:201,946,301–201,946,923 | 206.7 kb | Distal (>10kb) Multiome | 290 | |
| chr1:201,955,139–201,955,899 | 215.6 kb | Distal (>10kb) Multiome | 881 | |
| chr1:201,982,248–201,983,657 | 243.4 kb | Distal (>10kb) Multiome | 875 | |
| chr1:202,007,961–202,008,615 | 268.4 kb | Distal (>10kb) Multiome | 368 | |
| chr1:202,009,428–202,011,367 | 270.7 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the NAV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.