NAMPT

nicotinamide phosphoribosyltransferase | PBEF, PBEF1

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

Member of: DE-4 Developmental clusters: GC7

Biological processes 33 terms

NAD+ biosynthetic process (GO:0009435)NAD+ biosynthetic process (GO:0009435)NAD+ biosynthetic process via the salvage pathway (GO:0034355)NADP+ biosynthetic process (GO:0006741)adipose tissue development (GO:0060612)cell-cell signaling (GO:0007267)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)circadian rhythm (GO:0007623)cytokine activity (GO:0005125)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)identical protein binding (GO:0042802)identical protein binding (GO:0042802)inflammatory response (GO:0006954)insulin receptor signaling pathway (GO:0008286)mitochondrial matrix (GO:0005759)nicotinamide phosphoribosyltransferase activity (GO:0047280)nicotinamide phosphoribosyltransferase activity (GO:0047280)nicotinamide phosphoribosyltransferase activity (GO:0047280)nicotinamide phosphoribosyltransferase activity (GO:0047280)nicotinate metabolic process (GO:1901847)nucleus (GO:0005634)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of cell population proliferation (GO:0008284)positive regulation of gene expression (GO:0010628)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating NAMPT 0 TFs

Transcription factors with Perturb-seq knockdown data for NAMPT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAMPT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NAMPT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAMPT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:105,990,565–105,991,288	294.1 kb	Distal (>10kb) Multiome	112
chr7:106,009,291–106,010,280	275.3 kb	Distal (>10kb) Multiome	640
chr7:106,042,587–106,043,289	242.1 kb	Distal (>10kb) Multiome	430
chr7:106,111,676–106,113,209	172.6 kb	Distal (>10kb) Multiome	968
chr7:106,176,499–106,177,243	108.1 kb	Distal (>10kb) Multiome	473
chr7:106,283,900–106,286,008	208 bp	At TSS Multiome	996
chr7:106,417,157–106,417,851	132.5 kb	Distal (>10kb) Multiome	177

Genome Browser

Genomic view of the NAMPT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.