NAGK

N-acetylglucosamine kinase | GNK

This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

Member of: DE-1

Biological processes 21 terms

N-acetylglucosamine catabolic process (GO:0006046)N-acetylglucosamine kinase activity (GO:0045127)N-acetylglucosamine kinase activity (GO:0045127)N-acetylglucosamine kinase activity (GO:0045127)N-acetylglucosamine kinase activity (GO:0045127)N-acetylglucosamine metabolic process (GO:0006044)N-acetylglucosamine metabolic process (GO:0006044)N-acetylmannosamine metabolic process (GO:0006051)N-acetylneuraminate catabolic process (GO:0019262)N-acetylneuraminate catabolic process (GO:0019262)N-acylmannosamine kinase activity (GO:0009384)UDP-N-acetylglucosamine biosynthetic process (GO:0006048)cytosol (GO:0005829)defense response to bacterium (GO:0042742)extracellular exosome (GO:0070062)muramyl dipeptide kinase activity (GO:0160047)muramyl dipeptide kinase activity (GO:0160047)positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070434)positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070434)protein binding (GO:0005515)response to muramyl dipeptide (GO:0032495)

Expression (TPM)

TFs regulating NAGK 0 TFs

Transcription factors with Perturb-seq knockdown data for NAGK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAGK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NAGK

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAGK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:70,767,008–70,768,580	300.0 kb	Distal (>10kb) Multiome	463
chr2:70,887,498–70,887,945	180.5 kb	Distal (>10kb) Multiome	377
chr2:70,888,885–70,889,375	179.0 kb	Distal (>10kb) Multiome	192
chr2:70,899,864–70,901,996	167.8 kb	Distal (>10kb) Multiome	834
chr2:70,976,676–70,977,663	91.0 kb	Distal (>10kb) Multiome	372
chr2:70,978,404–70,979,416	89.3 kb	Distal (>10kb) Multiome	229
chr2:70,994,406–70,995,235	73.3 kb	Distal (>10kb) Multiome	805
chr2:71,067,597–71,069,479	246 bp	At TSS Multiome	1161
chr2:71,070,391–71,070,584	2.1 kb	Proximal (<10kb)	66
chr2:71,103,036–71,103,639	35.1 kb	Distal (>10kb) Multiome	56
chr2:71,129,728–71,130,863	62.1 kb	Distal (>10kb) Multiome	1092
chr2:71,226,288–71,227,849	159.0 kb	Distal (>10kb) Multiome	657
chr2:71,276,206–71,277,158	208.3 kb	Distal (>10kb) Multiome	790
chr2:71,331,200–71,332,517	263.5 kb	Distal (>10kb) Multiome	920

Genome Browser

Genomic view of the NAGK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.