The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NAE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,549,337–66,550,427 | 281.0 kb | Distal (>10kb) Multiome | 817 | |
| chr16:66,552,056–66,553,030 | 278.3 kb | Distal (>10kb) Multiome | 994 | |
| chr16:66,603,736–66,605,778 | 226.2 kb | Distal (>10kb) Multiome | 907 | |
| chr16:66,608,358–66,609,044 | 222.2 kb | Distal (>10kb) Multiome | 698 | |
| chr16:66,616,501–66,617,327 | 214.0 kb | Distal (>10kb) Multiome | 204 | |
| chr16:66,695,775–66,697,411 | 134.1 kb | Distal (>10kb) Multiome | 714 | |
| chr16:66,751,110–66,752,176 | 79.1 kb | Distal (>10kb) Multiome | 734 | |
| chr16:66,830,425–66,831,324 | 12 bp | At TSS Multiome | 934 | |
| chr16:66,844,097–66,844,861 | 13.5 kb | Distal (>10kb) Multiome | 211 | |
| chr16:66,872,965–66,873,714 | 42.4 kb | Distal (>10kb) Multiome | 836 | |
| chr16:66,880,003–66,881,270 | 49.6 kb | Distal (>10kb) Multiome | 1020 | |
| chr16:66,924,739–66,925,515 | 94.2 kb | Distal (>10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 103.5 kb | Distal (>10kb) Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 170.1 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 183.2 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 187.2 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 198.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 278.9 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the NAE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.