This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for NADK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NADK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NADK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:35,990,527–35,991,889 | 250.8 kb | Distal (>10kb) Multiome | 224 | |
| chr5:36,066,087–36,067,458 | 175.3 kb | Distal (>10kb) Multiome | 263 | |
| chr5:36,079,210–36,079,750 | 162.7 kb | Distal (>10kb) Multiome | 279 | |
| chr5:36,089,810–36,090,388 | 152.0 kb | Distal (>10kb) Multiome | 138 | |
| chr5:36,151,057–36,152,602 | 90.1 kb | Distal (>10kb) Multiome | 883 | |
| chr5:36,240,767–36,242,724 | 27 bp | At TSS Multiome | 1133 |
Genomic view of the NADK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.