Enables protein-N-terminal amino-acid acetyltransferase activity. Involved in protein stabilization. Located in cytosol and nucleus. Part of NatC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAA30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:57,268,159–57,269,344 | 121.9 kb | Distal (>10kb) Multiome | 916 | |
| chr14:57,364,988–57,365,748 | 25.3 kb | Distal (>10kb) Multiome | 54 | |
| chr14:57,383,112–57,383,500 | 7.1 kb | Proximal (<10kb) | 121 | |
| chr14:57,389,614–57,391,598 | 109 bp | At TSS Multiome | 779 | |
| chr14:57,473,378–57,474,215 | 83.2 kb | Distal (>10kb) Multiome | 31 | |
| chr14:57,598,346–57,599,001 | 208.0 kb | Distal (>10kb) Multiome | 16 |
Genomic view of the NAA30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.