NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]
Transcription factors with Perturb-seq knockdown data for NAA20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:18,507,260–18,508,352 | 1509.6 kb | Distal (>10kb) Multiome HiCAR | 959 | |
| chr20:19,757,220–19,759,328 | 259.3 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr20:20,009,940–20,010,182 | 7.2 kb | Proximal (<10kb) | 202 | |
| chr20:20,016,869–20,017,994 | 69 bp | At TSS Multiome | 994 | |
| chr20:20,051,953–20,052,929 | 35.2 kb | Distal (>10kb) Multiome | 945 | |
| chr20:20,102,068–20,103,125 | 85.5 kb | Distal (>10kb) Multiome | 37 | |
| chr20:20,134,692–20,135,494 | 117.7 kb | Distal (>10kb) Multiome | 124 |
Genomic view of the NAA20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.