N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for NAA10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:153,687,144–153,688,247 | 247.3 kb | Distal (>10kb) Multiome | 201 | |
| chrX:153,723,829–153,725,285 | 210.4 kb | Distal (>10kb) Multiome | 620 | |
| chrX:153,726,395–153,727,168 | 208.1 kb | Distal (>10kb) Multiome | 529 | |
| chrX:153,793,808–153,795,045 | 140.6 kb | Distal (>10kb) Multiome | 733 | |
| chrX:153,875,415–153,875,856 | 59.4 kb | Distal (>10kb) Multiome | 847 | |
| chrX:153,878,887–153,879,684 | 55.8 kb | Distal (>10kb) Multiome | 235 | |
| chrX:153,926,011–153,927,020 | 8.0 kb | Proximal (<10kb) | 493 | |
| chrX:153,927,955–153,928,728 | 6.6 kb | Proximal (<10kb) Multiome | 711 | |
| chrX:153,934,763–153,935,658 | 112 bp | At TSS Multiome | 446 | |
| chrX:153,970,913–153,973,065 | 37.4 kb | Distal (>10kb) Multiome | 857 | |
| chrX:154,097,040–154,098,161 | 162.8 kb | Distal (>10kb) Multiome | 537 | |
| chrX:154,136,648–154,137,146 | 201.8 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the NAA10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.