Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for N4BP2L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = N4BP2L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of N4BP2L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:32,314,935–32,316,400 | 223.2 kb | Distal (>10kb) Multiome | 896 | |
| chr13:32,409,564–32,410,449 | 128.9 kb | Distal (>10kb) Multiome | 262 | |
| chr13:32,426,853–32,428,509 | 111.4 kb | Distal (>10kb) Multiome | 737 | |
| chr13:32,537,977–32,539,319 | 81 bp | At TSS Multiome | 749 | |
| chr13:32,585,638–32,587,422 | 47.6 kb | Distal (>10kb) Multiome | 786 |
Genomic view of the N4BP2L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.