Enables RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for N4BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = N4BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of N4BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:48,365,312–48,366,772 | 244.2 kb | Distal (>10kb) Multiome | 826 | |
| chr16:48,384,395–48,386,081 | 224.7 kb | Distal (>10kb) Multiome | 865 | |
| chr16:48,609,338–48,610,591 | 41 bp | At TSS Multiome | 827 | |
| chr16:48,611,596–48,612,193 | 1.4 kb | Proximal (<10kb) | 198 | |
| chr16:48,623,055–48,623,916 | 13.2 kb | Distal (>10kb) Multiome | 714 | |
| chr16:49,280,046–49,283,454 | 671.9 kb | Distal (>10kb) Multiome HiCAR | 429 |
Genomic view of the N4BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.