This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for MYRF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYRF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYRF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,508,087–61,510,095 | 244.0 kb | Distal (>10kb) Multiome | 740 | |
| chr11:61,567,110–61,568,033 | 185.0 kb | Distal (>10kb) Multiome | 1078 | |
| chr11:61,580,454–61,581,871 | 171.3 kb | Distal (>10kb) Multiome | 760 | |
| chr11:61,587,343–61,588,726 | 164.3 kb | Distal (>10kb) Multiome | 271 | |
| chr11:61,680,168–61,680,631 | 72.3 kb | Distal (>10kb) Multiome | 532 | |
| chr11:61,747,560–61,748,157 | 4.8 kb | Proximal (<10kb) Multiome | 493 | |
| chr11:61,752,190–61,753,041 | 72 bp | At TSS Multiome | 329 | |
| chr11:61,792,046–61,793,394 | 40.1 kb | Distal (>10kb) Multiome | 896 | |
| chr11:61,814,541–61,817,407 | 62.6 kb | Distal (>10kb) Multiome | 1128 | |
| chr11:61,827,285–61,829,337 | 75.3 kb | Distal (>10kb) Multiome | 728 | |
| chr11:61,871,019–61,871,621 | 118.7 kb | Distal (>10kb) Multiome | 443 | |
| chr11:61,890,974–61,892,214 | 139.1 kb | Distal (>10kb) Multiome | 619 | |
| chr11:61,917,152–61,917,983 | 165.0 kb | Distal (>10kb) Multiome | 465 | |
| chr11:61,955,466–61,956,219 | 203.2 kb | Distal (>10kb) Multiome | 217 | |
| chr11:61,966,654–61,968,718 | 215.0 kb | Distal (>10kb) Multiome | 939 | |
| chr11:61,971,541–61,972,360 | 219.4 kb | Distal (>10kb) Multiome | 877 |
Genomic view of the MYRF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.