This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1) and neuroectodermal melanolysosomal disease, or Elejalde disease. [provided by RefSeq, Sep 2023]
Transcription factors with Perturb-seq knockdown data for MYO5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,261,434–52,262,154 | 267.0 kb | Distal (>10kb) Multiome | 313 | |
| chr15:52,294,913–52,296,036 | 233.1 kb | Distal (>10kb) Multiome | 630 | |
| chr15:52,392,159–52,392,836 | 136.4 kb | Distal (>10kb) Multiome | 167 | |
| chr15:52,528,126–52,529,827 | 129 bp | At TSS Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 40.2 kb | Distal (>10kb) Multiome | 996 | |
| chr15:52,677,739–52,679,973 | 150.6 kb | Distal (>10kb) Multiome | 913 | |
| chr15:52,699,116–52,699,867 | 170.7 kb | Distal (>10kb) Multiome | 140 | |
| chr15:52,709,542–52,710,221 | 181.0 kb | Distal (>10kb) Multiome | 335 | |
| chr15:52,745,306–52,746,160 | 216.9 kb | Distal (>10kb) Multiome | 166 | |
| chr15:52,783,424–52,785,757 | 254.8 kb | Distal (>10kb) Multiome | 397 | |
| chr15:52,789,439–52,791,791 | 261.5 kb | Distal (>10kb) Multiome | 633 | |
| chr15:52,798,074–52,799,220 | 270.0 kb | Distal (>10kb) Multiome | 184 | |
| chr15:52,804,516–52,806,560 | 276.9 kb | Distal (>10kb) Multiome | 322 |
Genomic view of the MYO5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.