Enables protein domain specific binding activity. Predicted to be involved in several processes, including actin filament organization; actin filament-based movement; and early endosome to recycling endosome transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYO1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:32,483,367–32,483,985 | 393.4 kb | Distal (>10kb) Multiome HiCAR | 306 | |
| chr17:32,486,205–32,487,756 | 390.4 kb | Distal (>10kb) Multiome HiCAR | 682 | |
| chr17:32,876,326–32,877,711 | 8 bp | At TSS Multiome | 744 | |
| chr17:32,927,748–32,928,442 | 50.9 kb | Distal (>10kb) Multiome | 374 | |
| chr17:32,936,823–32,937,295 | 59.9 kb | Distal (>10kb) Multiome | 344 |
Genomic view of the MYO1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.