This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYO1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,187,041–1,187,512 | 298.0 kb | Distal (>10kb) Multiome | 361 | |
| chr17:1,202,976–1,204,162 | 281.9 kb | Distal (>10kb) Multiome | 420 | |
| chr17:1,210,129–1,211,219 | 274.7 kb | Distal (>10kb) Multiome | 35 | |
| chr17:1,268,002–1,268,635 | 217.0 kb | Distal (>10kb) Multiome | 644 | |
| chr17:1,399,339–1,400,718 | 85.1 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,455,335–1,456,916 | 29.0 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,484,963–1,486,119 | 5 bp | At TSS Multiome | 562 | |
| chr17:1,486,754–1,487,591 | 994 bp | At TSS | 320 | |
| chr17:1,487,906–1,488,733 | 2.9 kb | Proximal (<10kb) Multiome | 597 | |
| chr17:1,490,717–1,492,156 | 6.1 kb | Proximal (<10kb) Multiome | 675 | |
| chr17:1,492,268–1,492,955 | 6.5 kb | Proximal (<10kb) | 221 | |
| chr17:1,515,722–1,517,330 | 31.4 kb | Distal (>10kb) Multiome | 796 | |
| chr17:1,562,314–1,563,047 | 77.5 kb | Distal (>10kb) Multiome | 685 | |
| chr17:1,589,843–1,590,457 | 104.7 kb | Distal (>10kb) Multiome | 538 | |
| chr17:1,627,811–1,629,617 | 143.4 kb | Distal (>10kb) Multiome | 753 | |
| chr17:1,642,697–1,644,482 | 157.9 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 163.8 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 199.5 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 225.1 kb | Distal (>10kb) Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 232.1 kb | Distal (>10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 239.4 kb | Distal (>10kb) Multiome | 720 |
Genomic view of the MYO1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.