The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MVD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MVD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MVD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,382,901–88,383,561 | 279.9 kb | Distal (>10kb) Multiome | 166 | |
| chr16:88,452,301–88,456,281 | 207.4 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:88,468,411–88,469,072 | 194.4 kb | Distal (>10kb) Multiome | 251 | |
| chr16:88,533,022–88,535,493 | 129.0 kb | Distal (>10kb) Multiome | 458 | |
| chr16:88,569,589–88,571,104 | 92.8 kb | Distal (>10kb) Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 28.5 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 12.0 kb | Distal (>10kb) Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 130 bp | At TSS Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 23.4 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 43.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 74.4 kb | Distal (>10kb) Multiome | 619 | |
| chr16:88,769,688–88,770,137 | 106.7 kb | Distal (>10kb) Multiome | 282 | |
| chr16:88,770,700–88,771,325 | 108.0 kb | Distal (>10kb) Multiome | 668 | |
| chr16:88,784,542–88,785,880 | 122.3 kb | Distal (>10kb) Multiome | 811 | |
| chr16:88,802,766–88,805,068 | 140.6 kb | Distal (>10kb) Multiome | 881 | |
| chr16:88,810,968–88,812,892 | 149.0 kb | Distal (>10kb) Multiome | 1059 | |
| chr16:88,856,080–88,858,003 | 193.9 kb | Distal (>10kb) Multiome | 885 | |
| chr16:88,940,964–88,942,110 | 278.8 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the MVD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.