The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for MUC3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MUC3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MUC3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,673,043–100,674,892 | 292.7 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 290.3 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 274.4 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 271.9 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 260.3 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 138.6 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 129.5 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 113.8 kb | Distal (>10kb) Multiome | 805 | |
| chr7:100,874,652–100,875,664 | 91.2 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 76.4 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 70.2 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 69.1 kb | Distal (>10kb) Multiome | 538 | |
| chr7:101,085,076–101,085,958 | 119.3 kb | Distal (>10kb) Multiome | 732 | |
| chr7:101,153,861–101,155,183 | 188.2 kb | Distal (>10kb) Multiome | 670 | |
| chr7:101,162,599–101,164,796 | 196.9 kb | Distal (>10kb) Multiome | 654 | |
| chr7:101,165,195–101,166,546 | 199.4 kb | Distal (>10kb) Multiome | 980 | |
| chr7:101,173,985–101,174,835 | 208.0 kb | Distal (>10kb) Multiome | 323 | |
| chr7:101,216,957–101,218,626 | 251.6 kb | Distal (>10kb) Multiome | 918 | |
| chr7:101,232,007–101,233,160 | 266.3 kb | Distal (>10kb) Multiome | 304 | |
| chr7:101,244,041–101,245,521 | 278.7 kb | Distal (>10kb) Multiome | 989 | |
| chr7:101,251,898–101,252,786 | 286.2 kb | Distal (>10kb) Multiome | 751 |
Genomic view of the MUC3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.