This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MTO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,262,731–73,263,555 | 198.6 kb | Distal (>10kb) Multiome | 460 | |
| chr6:73,314,466–73,315,532 | 146.8 kb | Distal (>10kb) Multiome | 137 | |
| chr6:73,348,234–73,349,695 | 112.3 kb | Distal (>10kb) Multiome | 281 | |
| chr6:73,388,539–73,389,752 | 72.7 kb | Distal (>10kb) Multiome | 579 | |
| chr6:73,450,878–73,452,652 | 9.7 kb | Proximal (<10kb) Multiome | 510 | |
| chr6:73,461,207–73,462,355 | 13 bp | At TSS Multiome | 806 | |
| chr6:73,511,142–73,516,574 | 52.6 kb | Distal (>10kb) Multiome | 913 | |
| chr6:73,520,105–73,522,117 | 59.5 kb | Distal (>10kb) Multiome | 1220 | |
| chr6:73,579,484–73,580,917 | 118.7 kb | Distal (>10kb) Multiome | 828 | |
| chr6:73,653,023–73,654,818 | 192.3 kb | Distal (>10kb) Multiome | 944 | |
| chr6:73,695,662–73,696,526 | 234.4 kb | Distal (>10kb) Multiome | 534 |
Genomic view of the MTO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.