This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MTMR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:150,566,477–150,567,226 | 126.5 kb | Distal (>10kb) Multiome | 251 | |
| chrX:150,568,001–150,569,320 | 124.8 kb | Distal (>10kb) Multiome | 620 | |
| chrX:150,689,261–150,689,439 | 3.9 kb | Proximal (<10kb) | 134 | |
| chrX:150,693,098–150,694,049 | 204 bp | At TSS Multiome | 435 | |
| chrX:150,898,166–150,899,720 | 205.4 kb | Distal (>10kb) Multiome | 562 | |
| chrX:150,902,225–150,902,784 | 209.2 kb | Distal (>10kb) Multiome | 187 | |
| chrX:150,982,738–150,984,074 | 289.8 kb | Distal (>10kb) Multiome | 454 |
Genomic view of the MTMR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.