Predicted to be involved in aerobic respiration and mitochondrial fission. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTFR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTFR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTFR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:135,497,226–135,498,795 | 752.5 kb | Distal (>10kb) Multiome HiCAR | 1084 | |
| chr6:136,249,441–136,251,347 | 89 bp | At TSS Multiome | 921 | |
| chr6:136,288,756–136,290,871 | 39.6 kb | Distal (>10kb) Multiome | 1158 | |
| chr6:136,526,121–136,527,142 | 276.3 kb | Distal (>10kb) Multiome | 235 | |
| chr6:136,549,356–136,551,131 | 300.3 kb | Distal (>10kb) Multiome | 722 |
Genomic view of the MTFR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.