MTF1

metal regulatory transcription factor 1

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

Member of: DE-5

Biological processes 28 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-templated transcription (GO:0006351)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular response to zinc ion (GO:0071294)central nervous system development (GO:0007417)cis-regulatory region sequence-specific DNA binding (GO:0000987)cis-regulatory region sequence-specific DNA binding (GO:0000987)cytoplasm (GO:0005737)histone acetyltransferase binding (GO:0035035)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)response to metal ion (GO:0010038)response to metal ion (GO:0010038)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating MTF1 0 TFs

Transcription factors with Perturb-seq knockdown data for MTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:37,595,631–37,596,377	263.6 kb	Distal (>10kb) Multiome	754
chr1:37,634,598–37,635,064	224.8 kb	Distal (>10kb) Multiome	192
chr1:37,663,328–37,663,865	196.0 kb	Distal (>10kb) Multiome	44
chr1:37,690,078–37,690,919	169.0 kb	Distal (>10kb) Multiome	679
chr1:37,691,459–37,692,843	167.2 kb	Distal (>10kb) Multiome	781
chr1:37,752,766–37,753,277	106.5 kb	Distal (>10kb) Multiome	223
chr1:37,793,768–37,794,528	65.5 kb	Distal (>10kb) Multiome	567
chr1:37,807,583–37,809,057	51.4 kb	Distal (>10kb) Multiome	755
chr1:37,859,081–37,860,381	139 bp	At TSS Multiome	939
chr1:37,931,446–37,932,215	72.3 kb	Distal (>10kb) Multiome	559
chr1:37,946,605–37,947,220	87.5 kb	Distal (>10kb) Multiome	610
chr1:37,989,644–37,990,549	130.6 kb	Distal (>10kb) Multiome	1133
chr1:37,995,790–37,996,610	136.6 kb	Distal (>10kb) Multiome	313
chr1:38,004,771–38,006,024	146.0 kb	Distal (>10kb) Multiome	442
chr1:38,012,220–38,013,284	153.0 kb	Distal (>10kb) Multiome	1074
chr1:38,030,338–38,030,974	170.9 kb	Distal (>10kb) Multiome	225
chr1:38,045,344–38,048,035	187.4 kb	Distal (>10kb) Multiome	542

Genome Browser

Genomic view of the MTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.