This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MTCP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTCP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTCP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:154,805,199–154,805,850 | 265.6 kb | Distal (>10kb) Multiome | 481 | |
| chrX:155,026,631–155,027,442 | 44.2 kb | Distal (>10kb) Multiome | 744 | |
| chrX:155,070,784–155,072,076 | 189 bp | At TSS Multiome | 561 | |
| chrX:155,215,967–155,217,001 | 145.3 kb | Distal (>10kb) Multiome | 532 | |
| chrX:155,263,993–155,264,650 | 193.3 kb | Distal (>10kb) Multiome | 381 |
Genomic view of the MTCP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.