This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]
Transcription factors with Perturb-seq knockdown data for MTAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:21,334,615–21,335,758 | 467.3 kb | Distal (>10kb) Multiome HiCAR | 770 | |
| chr9:21,402,228–21,403,414 | 399.8 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr9:21,504,615–21,505,684 | 297.5 kb | Distal (>10kb) Multiome | 144 | |
| chr9:21,559,092–21,560,760 | 242.8 kb | Distal (>10kb) Multiome | 437 | |
| chr9:21,696,089–21,697,126 | 106.0 kb | Distal (>10kb) Multiome | 185 | |
| chr9:21,751,963–21,752,478 | 50.4 kb | Distal (>10kb) Multiome | 156 | |
| chr9:21,801,496–21,803,636 | 55 bp | At TSS Multiome | 911 | |
| chr9:21,854,198–21,854,432 | 290 bp | At TSS | 26 | |
| chr9:21,968,166–21,969,501 | 166.5 kb | Distal (>10kb) Multiome | 181 | |
| chr9:21,974,429–21,975,677 | 172.3 kb | Distal (>10kb) Multiome | 502 | |
| chr9:21,993,764–21,996,459 | 192.9 kb | Distal (>10kb) Multiome HiCAR | 632 | |
| chr9:22,005,147–22,006,417 | 202.9 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr9:22,008,480–22,009,778 | 206.6 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr9:22,238,768–22,240,023 | 436.7 kb | Distal (>10kb) Multiome HiCAR | 373 |
Genomic view of the MTAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.