MSH5

mutS homolog 5 | G7

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]

Member of: DE-5

Biological processes 10 terms

ATP binding (GO:0005524)ATP-dependent DNA damage sensor activity (GO:0140664)chiasma assembly (GO:0051026)double-stranded DNA binding (GO:0003690)meiosis I (GO:0007127)mismatch repair (GO:0006298)mismatched DNA binding (GO:0030983)nucleus (GO:0005634)protein binding (GO:0005515)reciprocal meiotic recombination (GO:0007131)

Expression (TPM)

TFs regulating MSH5 0 TFs

Transcription factors with Perturb-seq knockdown data for MSH5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSH5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MSH5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSH5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,441,682–31,442,105	298.1 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	276.9 kb	Distal (>10kb) Multiome	352
chr6:31,497,638–31,498,615	241.9 kb	Distal (>10kb) Multiome	613
chr6:31,541,205–31,542,816	197.9 kb	Distal (>10kb) Multiome	1073
chr6:31,546,485–31,547,136	193.2 kb	Distal (>10kb) Multiome	589
chr6:31,547,301–31,547,742	192.3 kb	Distal (>10kb) Multiome	762
chr6:31,580,713–31,581,330	158.9 kb	Distal (>10kb) Multiome	745
chr6:31,619,744–31,621,435	119.4 kb	Distal (>10kb) Multiome	1127
chr6:31,651,682–31,653,297	87.3 kb	Distal (>10kb) Multiome	1113
chr6:31,660,325–31,660,941	79.1 kb	Distal (>10kb) Multiome	892
chr6:31,664,725–31,666,373	75.1 kb	Distal (>10kb) Multiome	1039
chr6:31,682,887–31,683,880	56.6 kb	Distal (>10kb) Multiome HiCAR	248
chr6:31,702,816–31,703,520	36.7 kb	Distal (>10kb) Multiome	875
chr6:31,713,576–31,714,641	25.8 kb	Distal (>10kb) Multiome	171
chr6:31,728,852–31,730,814	9.7 kb	Proximal (<10kb) Multiome	979
chr6:31,734,710–31,735,156	4.8 kb	Proximal (<10kb)	570
chr6:31,736,263–31,736,697	3.2 kb	Proximal (<10kb)	727
chr6:31,738,486–31,738,918	1.0 kb	Proximal (<10kb)	609
chr6:31,739,236–31,740,741	42 bp	At TSS Multiome	1043
chr6:31,766,045–31,766,778	26.5 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	56.0 kb	Distal (>10kb) Multiome	979
chr6:31,806,162–31,807,183	67.0 kb	Distal (>10kb) Multiome	947
chr6:31,814,125–31,815,936	74.7 kb	Distal (>10kb) Multiome	822
chr6:31,818,020–31,818,663	78.4 kb	Distal (>10kb) Multiome	280
chr6:31,821,306–31,822,544	82.1 kb	Distal (>10kb) Multiome	714
chr6:31,826,770–31,828,135	87.6 kb	Distal (>10kb) Multiome	1000
chr6:31,834,277–31,835,371	94.8 kb	Distal (>10kb) Multiome	1085
chr6:31,862,148–31,864,173	123.0 kb	Distal (>10kb) Multiome	1118
chr6:31,896,965–31,898,037	157.6 kb	Distal (>10kb) Multiome	654
chr6:31,901,114–31,902,643	162.3 kb	Distal (>10kb) Multiome	826
chr6:31,958,527–31,959,598	219.1 kb	Distal (>10kb) Multiome	953
chr6:31,971,421–31,972,872	232.3 kb	Distal (>10kb) Multiome	1059

Genome Browser

Genomic view of the MSH5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.