Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPS26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:2,752,636–2,753,047 | 293.3 kb | Distal (>10kb) Multiome | 395 | |
| chr20:2,800,326–2,801,021 | 245.3 kb | Distal (>10kb) Multiome | 349 | |
| chr20:2,840,006–2,841,330 | 205.4 kb | Distal (>10kb) Multiome | 997 | |
| chr20:2,872,329–2,874,047 | 172.5 kb | Distal (>10kb) Multiome | 980 | |
| chr20:3,045,415–3,046,996 | 116 bp | At TSS Multiome | 999 | |
| chr20:3,071,569–3,072,466 | 26.2 kb | Distal (>10kb) Multiome | 214 | |
| chr20:3,092,619–3,093,442 | 47.0 kb | Distal (>10kb) Multiome | 180 | |
| chr20:3,159,566–3,160,153 | 113.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr20:3,168,012–3,168,864 | 122.4 kb | Distal (>10kb) Multiome | 598 | |
| chr20:3,172,885–3,174,573 | 127.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr20:3,203,485–3,204,801 | 158.5 kb | Distal (>10kb) Multiome | 952 | |
| chr20:3,218,394–3,218,992 | 172.6 kb | Distal (>10kb) Multiome | 638 | |
| chr20:3,238,062–3,240,422 | 193.4 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the MRPS26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.