This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for MRPL9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,491,747–151,492,512 | 271.3 kb | Distal (>10kb) Multiome | 146 | |
| chr1:151,502,459–151,503,303 | 260.6 kb | Distal (>10kb) Multiome | 99 | |
| chr1:151,510,863–151,512,136 | 252.2 kb | Distal (>10kb) Multiome | 640 | |
| chr1:151,539,661–151,541,320 | 223.2 kb | Distal (>10kb) Multiome | 830 | |
| chr1:151,611,789–151,613,070 | 151.4 kb | Distal (>10kb) Multiome | 761 | |
| chr1:151,721,370–151,721,843 | 41.9 kb | Distal (>10kb) Multiome | 186 | |
| chr1:151,762,987–151,763,859 | 4 bp | At TSS Multiome | 848 | |
| chr1:151,790,055–151,791,612 | 27.1 kb | Distal (>10kb) Multiome | 953 | |
| chr1:151,839,238–151,840,386 | 76.3 kb | Distal (>10kb) Multiome | 493 | |
| chr1:151,909,150–151,910,123 | 146.1 kb | Distal (>10kb) Multiome | 983 | |
| chr1:151,936,340–151,937,120 | 173.4 kb | Distal (>10kb) Multiome | 185 | |
| chr1:151,992,346–151,994,801 | 230.5 kb | Distal (>10kb) Multiome | 709 | |
| chr1:152,034,408–152,035,398 | 271.3 kb | Distal (>10kb) Multiome | 590 | |
| chr1:152,036,267–152,037,471 | 273.5 kb | Distal (>10kb) Multiome | 586 | |
| chr1:152,047,642–152,048,726 | 284.7 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the MRPL9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.