Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,556,665–22,557,670 | 272.7 kb | Distal (>10kb) Multiome HiCAR | 771 | |
| chr14:22,560,678–22,561,385 | 268.9 kb | Distal (>10kb) Multiome HiCAR | 502 | |
| chr14:22,570,258–22,571,116 | 259.4 kb | Distal (>10kb) Multiome HiCAR | 460 | |
| chr14:22,588,929–22,590,086 | 240.4 kb | Distal (>10kb) Multiome | 964 | |
| chr14:22,597,878–22,599,136 | 231.6 kb | Distal (>10kb) Multiome | 834 | |
| chr14:22,766,419–22,767,375 | 63.2 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,819,584–22,819,976 | 9.9 kb | Proximal (<10kb) | 264 | |
| chr14:22,821,826–22,823,530 | 7.0 kb | Proximal (<10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 44 bp | At TSS Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 6.6 kb | Proximal (<10kb) Multiome | 320 | |
| chr14:22,837,269–22,838,446 | 7.4 kb | Proximal (<10kb) | 512 | |
| chr14:22,852,845–22,853,709 | 23.4 kb | Distal (>10kb) Multiome HiCAR | 788 | |
| chr14:22,870,967–22,873,202 | 41.7 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 53.3 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 57.3 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 89.4 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 99.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 127.2 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 152.8 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 177.3 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 191.1 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 271.7 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the MRPL52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.