Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for MRPL48. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL48 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL48, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,597,688–73,598,911 | 189.6 kb | Distal (>10kb) Multiome | 887 | |
| chr11:73,645,683–73,646,788 | 141.6 kb | Distal (>10kb) Multiome | 193 | |
| chr11:73,647,445–73,647,968 | 140.2 kb | Distal (>10kb) Multiome | 442 | |
| chr11:73,660,644–73,661,627 | 126.7 kb | Distal (>10kb) Multiome | 525 | |
| chr11:73,760,242–73,761,712 | 26.6 kb | Distal (>10kb) Multiome | 842 | |
| chr11:73,779,162–73,780,136 | 8.2 kb | Proximal (<10kb) Multiome | 920 | |
| chr11:73,784,319–73,784,621 | 3.3 kb | Proximal (<10kb) | 450 | |
| chr11:73,787,771–73,788,337 | 223 bp | At TSS Multiome | 1000 | |
| chr11:73,876,432–73,877,378 | 89.0 kb | Distal (>10kb) Multiome | 911 | |
| chr11:73,982,330–73,983,905 | 195.3 kb | Distal (>10kb) Multiome | 1122 |
Genomic view of the MRPL48 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.