MRPL34

mitochondrial ribosomal protein L34 | L34mt, MGC24974, MGC2633, bL34m

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.21

Biological processes 14 terms

mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial large ribosomal subunit (GO:0005762)mitochondrial large ribosomal subunit (GO:0005762)mitochondrial ribosome (GO:0005761)mitochondrial translation (GO:0032543)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)ribosome (GO:0005840)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)translation (GO:0006412)translation (GO:0006412)

Expression (TPM)

TFs regulating MRPL34 0 TFs

Transcription factors with Perturb-seq knockdown data for MRPL34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MRPL34

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	217.0 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	82.8 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	77.1 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	66.2 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	56.7 kb	Distal (>10kb) Multiome	612
chr19:17,244,882–17,247,104	46.5 kb	Distal (>10kb) Multiome	862
chr19:17,247,935–17,248,860	44.0 kb	Distal (>10kb) Multiome	588
chr19:17,266,931–17,267,755	25.4 kb	Distal (>10kb) Multiome	720
chr19:17,281,537–17,283,120	9.8 kb	Proximal (<10kb) Multiome	669
chr19:17,289,587–17,289,821	2.8 kb	Proximal (<10kb)	128
chr19:17,292,242–17,293,049	81 bp	At TSS Multiome	513
chr19:17,294,076–17,294,320	1.5 kb	Proximal (<10kb)	192
chr19:17,302,721–17,303,771	10.8 kb	Distal (>10kb) Multiome	636
chr19:17,305,286–17,306,514	13.1 kb	Distal (>10kb) Multiome	947
chr19:17,309,159–17,310,151	16.9 kb	Distal (>10kb) Multiome	741
chr19:17,327,532–17,329,548	35.4 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	42.2 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	44.9 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	48.0 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	98.6 kb	Distal (>10kb) Multiome	615
chr19:17,394,998–17,395,433	102.6 kb	Distal (>10kb) Multiome	403
chr19:17,398,863–17,399,537	106.6 kb	Distal (>10kb) Multiome	132
chr19:17,403,087–17,404,355	110.9 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	127.3 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	132.5 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	156.0 kb	Distal (>10kb) Multiome	392
chr19:17,468,858–17,470,905	177.5 kb	Distal (>10kb) Multiome	743
chr19:17,488,739–17,489,689	196.6 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	218.9 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	247.2 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	263.0 kb	Distal (>10kb) Multiome	713
chr19:17,576,463–17,577,455	284.4 kb	Distal (>10kb) Multiome	236
chr19:17,579,580–17,580,242	287.4 kb	Distal (>10kb) Multiome	281

Genome Browser

Genomic view of the MRPL34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.