Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:75,432,824–75,433,639 | 213.5 kb | Distal (>10kb) Multiome | 162 | |
| chr2:75,559,894–75,561,359 | 85.8 kb | Distal (>10kb) Multiome | 758 | |
| chr2:75,608,794–75,609,384 | 37.6 kb | Distal (>10kb) Multiome | 497 | |
| chr2:75,640,625–75,640,813 | 6.0 kb | Proximal (<10kb) | 274 | |
| chr2:75,646,232–75,647,394 | 37 bp | At TSS Multiome | 967 | |
| chr2:75,710,352–75,711,465 | 64.0 kb | Distal (>10kb) Multiome | 1066 |
Genomic view of the MRPL19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.