Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for MRPL10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,531,659–47,532,268 | 299.3 kb | Distal (>10kb) Multiome | 159 | |
| chr17:47,648,863–47,650,987 | 181.9 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 137.1 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 98.3 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 41.5 kb | Distal (>10kb) Multiome | 395 | |
| chr17:47,821,699–47,822,014 | 9.5 kb | Proximal (<10kb) | 639 | |
| chr17:47,831,256–47,831,955 | 38 bp | At TSS Multiome | 856 | |
| chr17:47,840,790–47,841,702 | 9.8 kb | Proximal (<10kb) Multiome | 833 | |
| chr17:47,847,253–47,848,429 | 16.2 kb | Distal (>10kb) Multiome | 193 | |
| chr17:47,850,617–47,851,614 | 19.6 kb | Distal (>10kb) Multiome | 694 | |
| chr17:47,895,361–47,896,955 | 64.6 kb | Distal (>10kb) Multiome HiCAR | 1031 | |
| chr17:47,902,020–47,902,508 | 70.6 kb | Distal (>10kb) Multiome | 101 | |
| chr17:47,941,283–47,941,880 | 110.0 kb | Distal (>10kb) Multiome | 958 | |
| chr17:47,970,487–47,971,547 | 139.4 kb | Distal (>10kb) Multiome | 1061 | |
| chr17:48,023,351–48,024,470 | 192.1 kb | Distal (>10kb) Multiome | 591 | |
| chr17:48,024,599–48,025,777 | 193.7 kb | Distal (>10kb) Multiome | 759 | |
| chr17:48,026,284–48,026,933 | 195.2 kb | Distal (>10kb) Multiome | 543 | |
| chr17:48,047,576–48,049,198 | 216.7 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:48,053,836–48,055,155 | 223.0 kb | Distal (>10kb) Multiome | 327 | |
| chr17:48,055,581–48,056,000 | 224.4 kb | Distal (>10kb) Multiome | 337 | |
| chr17:48,100,593–48,101,963 | 269.9 kb | Distal (>10kb) Multiome | 974 | |
| chr17:48,107,198–48,108,007 | 276.1 kb | Distal (>10kb) Multiome | 841 |
Genomic view of the MRPL10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.