This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for MRAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:83,852,941–83,854,471 | 180.2 kb | Distal (>10kb) Multiome | 497 | |
| chr6:83,859,075–83,860,410 | 174.1 kb | Distal (>10kb) Multiome | 1062 | |
| chr6:84,033,204–84,034,688 | 65 bp | At TSS Multiome | 473 | |
| chr6:84,052,161–84,053,196 | 18.9 kb | Distal (>10kb) Multiome | 417 | |
| chr6:84,086,644–84,088,326 | 53.5 kb | Distal (>10kb) Multiome | 191 | |
| chr6:84,139,828–84,140,912 | 106.6 kb | Distal (>10kb) Multiome | 99 | |
| chr6:84,227,112–84,228,449 | 193.9 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the MRAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.