Enables mitochondrial large ribosomal subunit binding activity. Involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MPV17L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPV17L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPV17L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,931,700–17,932,248 | 261.4 kb | Distal (>10kb) Multiome | 136 | |
| chr19:17,932,373–17,933,607 | 260.4 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,942,639–17,943,673 | 249.9 kb | Distal (>10kb) Multiome | 302 | |
| chr19:17,947,203–17,950,613 | 245.2 kb | Distal (>10kb) Multiome | 639 | |
| chr19:17,951,201–17,952,652 | 241.0 kb | Distal (>10kb) Multiome | 237 | |
| chr19:17,966,756–17,967,353 | 226.2 kb | Distal (>10kb) Multiome | 127 | |
| chr19:18,000,754–18,001,614 | 192.1 kb | Distal (>10kb) Multiome | 788 | |
| chr19:18,007,024–18,008,451 | 185.1 kb | Distal (>10kb) Multiome | 681 | |
| chr19:18,058,070–18,058,878 | 134.7 kb | Distal (>10kb) Multiome | 542 | |
| chr19:18,104,219–18,104,847 | 88.7 kb | Distal (>10kb) Multiome | 466 | |
| chr19:18,109,636–18,110,594 | 83.2 kb | Distal (>10kb) Multiome | 601 | |
| chr19:18,117,556–18,118,528 | 75.3 kb | Distal (>10kb) Multiome | 550 | |
| chr19:18,152,230–18,153,823 | 40.4 kb | Distal (>10kb) Multiome | 809 | |
| chr19:18,160,950–18,161,791 | 31.8 kb | Distal (>10kb) Multiome | 494 | |
| chr19:18,173,513–18,174,441 | 19.5 kb | Distal (>10kb) Multiome | 667 | |
| chr19:18,192,530–18,193,908 | 224 bp | At TSS Multiome | 758 | |
| chr19:18,202,796–18,205,452 | 11.0 kb | Distal (>10kb) Multiome | 823 | |
| chr19:18,220,660–18,221,487 | 27.8 kb | Distal (>10kb) Multiome | 134 | |
| chr19:18,223,665–18,226,306 | 30.8 kb | Distal (>10kb) Multiome | 790 | |
| chr19:18,232,737–18,233,413 | 39.9 kb | Distal (>10kb) Multiome | 789 | |
| chr19:18,278,462–18,282,788 | 88.5 kb | Distal (>10kb) Multiome | 1184 | |
| chr19:18,287,827–18,288,359 | 94.7 kb | Distal (>10kb) Multiome | 221 | |
| chr19:18,291,350–18,293,764 | 98.8 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:18,322,635–18,323,493 | 130.0 kb | Distal (>10kb) Multiome | 814 | |
| chr19:18,328,417–18,328,936 | 135.4 kb | Distal (>10kb) Multiome | 488 | |
| chr19:18,339,807–18,340,160 | 146.7 kb | Distal (>10kb) Multiome | 249 | |
| chr19:18,340,428–18,341,393 | 147.3 kb | Distal (>10kb) Multiome | 747 | |
| chr19:18,373,917–18,374,961 | 181.3 kb | Distal (>10kb) Multiome | 971 | |
| chr19:18,388,239–18,388,884 | 195.3 kb | Distal (>10kb) Multiome | 910 | |
| chr19:18,416,224–18,418,189 | 223.4 kb | Distal (>10kb) Multiome | 893 | |
| chr19:18,418,296–18,420,432 | 226.2 kb | Distal (>10kb) Multiome | 773 | |
| chr19:18,428,554–18,429,777 | 235.9 kb | Distal (>10kb) Multiome | 489 | |
| chr19:18,433,114–18,434,328 | 240.9 kb | Distal (>10kb) Multiome | 446 | |
| chr19:18,436,634–18,439,166 | 244.0 kb | Distal (>10kb) Multiome | 799 |
Genomic view of the MPV17L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.