Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MPP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,694,216–43,694,699 | 206.1 kb | Distal (>10kb) Multiome | 408 | |
| chr17:43,720,542–43,721,150 | 179.8 kb | Distal (>10kb) Multiome | 572 | |
| chr17:43,755,308–43,755,795 | 145.1 kb | Distal (>10kb) Multiome | 248 | |
| chr17:43,760,231–43,760,686 | 140.1 kb | Distal (>10kb) Multiome | 539 | |
| chr17:43,778,079–43,779,460 | 121.8 kb | Distal (>10kb) Multiome | 937 | |
| chr17:43,832,658–43,833,385 | 67.4 kb | Distal (>10kb) Multiome | 455 | |
| chr17:43,900,207–43,900,990 | 75 bp | At TSS Multiome | 308 | |
| chr17:43,906,025–43,906,856 | 6.0 kb | Proximal (<10kb) Multiome | 353 | |
| chr17:43,907,081–43,907,899 | 7.1 kb | Proximal (<10kb) Multiome | 362 | |
| chr17:43,908,133–43,908,338 | 7.5 kb | Proximal (<10kb) | 230 | |
| chr17:43,910,277–43,910,457 | 9.7 kb | Proximal (<10kb) | 93 | |
| chr17:43,937,932–43,938,382 | 37.6 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 52.5 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 83.4 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 104.1 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 114.3 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 166.0 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 170.2 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 195.4 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 210.7 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 223.2 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 241.3 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 268.0 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 286.2 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 299.6 kb | Distal (>10kb) Multiome | 868 |
Genomic view of the MPP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.