Predicted to enable RNA binding activity. Involved in maturation of 5.8S rRNA. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MPHOSPH6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPHOSPH6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPHOSPH6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:82,169,820–82,170,830 | 62 bp | At TSS Multiome | 1026 | |
| chr16:82,229,526–82,230,317 | 59.8 kb | Distal (>10kb) Multiome | 255 | |
| chr16:82,439,575–82,441,128 | 270.3 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the MPHOSPH6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.