This gene encodes an endoplasmic reticulum membrane protein that is required for utilization of the mannose donor mannose-P-dolichol in the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositols. Mutations in this gene result in congenital disorder of glycosylation type If. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for MPDU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPDU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPDU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,293,901–7,295,189 | 289.1 kb | Distal (>10kb) Multiome | 443 | |
| chr17:7,296,224–7,296,683 | 287.2 kb | Distal (>10kb) Multiome | 688 | |
| chr17:7,306,788–7,309,027 | 276.4 kb | Distal (>10kb) Multiome | 896 | |
| chr17:7,314,722–7,315,725 | 268.5 kb | Distal (>10kb) Multiome | 843 | |
| chr17:7,328,881–7,330,972 | 254.3 kb | Distal (>10kb) Multiome | 809 | |
| chr17:7,349,378–7,350,590 | 233.6 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,351,208–7,352,575 | 231.8 kb | Distal (>10kb) Multiome | 857 | |
| chr17:7,356,082–7,356,523 | 227.6 kb | Distal (>10kb) Multiome | 485 | |
| chr17:7,383,791–7,384,537 | 199.6 kb | Distal (>10kb) Multiome | 218 | |
| chr17:7,393,924–7,395,223 | 189.1 kb | Distal (>10kb) Multiome | 744 | |
| chr17:7,403,290–7,405,695 | 179.5 kb | Distal (>10kb) Multiome | 838 | |
| chr17:7,435,167–7,437,681 | 146.7 kb | Distal (>10kb) Multiome | 828 | |
| chr17:7,437,892–7,438,555 | 145.5 kb | Distal (>10kb) Multiome | 224 | |
| chr17:7,440,048–7,441,211 | 143.1 kb | Distal (>10kb) Multiome | 487 | |
| chr17:7,444,968–7,446,142 | 138.2 kb | Distal (>10kb) Multiome | 632 | |
| chr17:7,455,450–7,456,019 | 128.2 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,478,839–7,480,126 | 104.3 kb | Distal (>10kb) Multiome | 574 | |
| chr17:7,483,139–7,485,576 | 99.4 kb | Distal (>10kb) Multiome | 1156 | |
| chr17:7,548,693–7,549,285 | 34.8 kb | Distal (>10kb) Multiome | 387 | |
| chr17:7,560,249–7,562,536 | 21.9 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,572,039–7,574,418 | 9.9 kb | Proximal (<10kb) Multiome | 1071 | |
| chr17:7,579,018–7,579,876 | 4.4 kb | Proximal (<10kb) Multiome | 844 | |
| chr17:7,583,063–7,584,547 | 42 bp | At TSS Multiome | 921 | |
| chr17:7,588,871–7,590,534 | 6.3 kb | Proximal (<10kb) Multiome | 319 | |
| chr17:7,590,769–7,591,007 | 6.9 kb | Proximal (<10kb) | 125 | |
| chr17:7,614,065–7,615,780 | 31.3 kb | Distal (>10kb) Multiome | 708 | |
| chr17:7,627,090–7,628,247 | 44.0 kb | Distal (>10kb) Multiome | 712 | |
| chr17:7,650,010–7,652,127 | 67.0 kb | Distal (>10kb) Multiome | 467 | |
| chr17:7,685,876–7,686,907 | 102.5 kb | Distal (>10kb) Multiome | 765 | |
| chr17:7,687,214–7,687,777 | 103.7 kb | Distal (>10kb) Multiome | 710 | |
| chr17:7,687,867–7,688,863 | 104.5 kb | Distal (>10kb) Multiome | 700 | |
| chr17:7,703,383–7,703,975 | 119.8 kb | Distal (>10kb) Multiome | 141 | |
| chr17:7,704,799–7,705,590 | 121.3 kb | Distal (>10kb) Multiome | 325 | |
| chr17:7,716,832–7,717,983 | 133.5 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,833,417–7,837,960 | 251.8 kb | Distal (>10kb) Multiome | 1160 | |
| chr17:7,841,438–7,843,228 | 258.4 kb | Distal (>10kb) Multiome | 861 | |
| chr17:7,843,355–7,844,130 | 259.8 kb | Distal (>10kb) Multiome | 614 | |
| chr17:7,844,349–7,845,186 | 261.1 kb | Distal (>10kb) Multiome | 617 | |
| chr17:7,851,538–7,852,239 | 268.0 kb | Distal (>10kb) Multiome | 531 | |
| chr17:7,856,600–7,858,747 | 273.7 kb | Distal (>10kb) Multiome | 942 |
Genomic view of the MPDU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.