Predicted to be involved in negative regulation of smoothened signaling pathway; regulation of neuron differentiation; and regulation of protein stability. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic limb morphogenesis; and smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and ciliary membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MOSMO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOSMO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOSMO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:21,952,487–21,953,795 | 55.0 kb | Distal (>10kb) Multiome | 1014 | |
| chr16:22,001,072–22,001,263 | 6.8 kb | Proximal (<10kb) | 541 | |
| chr16:22,007,549–22,008,682 | 94 bp | At TSS Multiome | 685 | |
| chr16:22,189,506–22,191,692 | 182.7 kb | Distal (>10kb) Multiome | 989 | |
| chr16:22,195,474–22,196,347 | 187.8 kb | Distal (>10kb) Multiome | 886 | |
| chr16:22,205,924–22,206,847 | 198.1 kb | Distal (>10kb) Multiome | 1038 | |
| chr16:22,296,790–22,298,718 | 290.5 kb | Distal (>10kb) Multiome | 1288 |
Genomic view of the MOSMO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.